The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 23, 2025
Filed:
Nov. 27, 2020
Applicant:
Wuhan Ll Science and Technology Development Co., Ltd., Hubei, CN;
Inventors:
Jun Lou, Hubei, CN;
Yongkai Chen, Hubei, CN;
Yihan Zhang, Hubei, CN;
Xiaodan Guo, Hubei, CN;
Lina Qian, Hubei, CN;
Li Liu, Hubei, CN;
Wei Peng, Hubei, CN;
Fei Rong, Hubei, CN;
Chaodong Wang, Hubei, CN;
Assignee:
Primary Examiner:
Int. Cl.
CPC ...
C07D 231/56 (2006.01); C07D 209/44 (2006.01); C07D 235/24 (2006.01); C07D 401/06 (2006.01); C07D 405/04 (2006.01); C07D 405/06 (2006.01);
U.S. Cl.
CPC ...
C07D 231/56 (2013.01); C07D 209/44 (2013.01); C07D 235/24 (2013.01); C07D 401/06 (2013.01); C07D 405/04 (2013.01); C07D 405/06 (2013.01);
Abstract
A compound containing a benzene ring as shown in formula I, a pharmaceutically acceptable salt thereof, a stereoisomer thereof, a tautomer thereof, an isotopic compound thereof, a crystal form thereof, a nitrogen oxide thereof, and a solvate thereof or a solvate of the pharmaceutically acceptable salt thereof are provided. The compound has high P2X4 antagonistic activity, good selectivity, low toxicity and good metabolic stability.