The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 23, 2025
Filed:
Oct. 27, 2022
Jiangnan University, Wuxi, CN;
Wei Chen, Wuxi, CN;
Qiuxiang Zhang, Wuxi, CN;
Wanqing Xu, Wuxi, CN;
Wenwei Lu, Wuxi, CN;
Hao Zhang, Wuxi, CN;
Jianxin Zhao, Wuxi, CN;
Jiangnan University, Wuxi, CN;
Abstract
The present disclosure discloses a strain ofcapable of preventing and/or treating periodontitis and an application thereof, belonging to the field of microbiology technology. The present disclosure has screened to obtain a strain ofCCFM1139. TheCCFM1139 can alleviate periodontitis by inhibiting formation of mixed bacterial biofilms ofand, thereby reducing the amount of biofilm by 52.45%, and can reduce the content of TNF-α from 131.37 pg/mL to 83.31 pg/mL and IL-8 from 147.70 pg/mL to 121.12 pg/mL in a periodontitis cell model, reduce colonization of theand thein the oral cavity by 1-2 orders of magnitude, and reduce the amount of the alveolar bone resorption from 1838.0 μm to 805.7 μm.