The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 01, 2025
Filed:
Jun. 19, 2020
Hoffmann-la Roche Inc., Little Falls, NJ (US);
Cosimo Dolente, Allschwil, CH;
Annick Goergler, Colmar, FR;
David Hewings, Basel, CH;
Georg Jaeschke, Basel, CH;
Bernd Kuhn, Reinach, CH;
Yvonne Alice Nagel, Basel, CH;
Christa Ulrike Obst-Sander, Reinach BL, CH;
Antonio Ricci, Biel-Benken, CH;
Daniel Rueher, Raedersdorf, FR;
Sandra Steiner, Sursee, CH;
Hoffmann-La Roche Inc., Little Falls, NJ (US);
Abstract
The application relates to a compound of formula (I) containing a thiazole ring, an indazol ring and a 6,7-dihydro-5H-pyrrolo[1,2-c]imidazole ring system, to pharmaceutical compositions containing it and its medical use. The compounds are described as selective allosteric inhibitors of T790M/L858R, T790M/L858R/C797S, L858R, L858R/C797S containing EGFR mutants and thus useful for the treatment of cancer, in particular non-small cell lung cancer.