The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 11, 2025
Filed:
Oct. 05, 2018
Novo Nordisk A/s, Bagsvaerd, DK;
Joshua Reginald Salmans, South San Francisco, CA (US);
Svetlana Alexander, Sunnyvale, CA (US);
Robin Barbour, Walnut Creek, CA (US);
Jianmin Li, Castro Valley, CA (US);
Jeffrey N. Higaki, San Mateo, CA (US);
Tarlochan S. Nijjar, Orinda, CA (US);
NOVO NORDISK A/S, Bagsvaerd, DK;
Abstract
The invention provides methods of detecting transthyretin (TTR) using a capture antibody and a reporter antibody. The capture antibody binds preferentially to misfolded TTR over native tetrameric form of TTR. The capture antibody binds to an epitope within amino acid residues 89-97 or TTR or to an epitope within amino acid residues 101-109 of TTR. 9D5 and 18C5 are examples of suitable capture antibodies. The methods can be used for diagnosing diseases or disorders associated with TTR accumulation or accumulation of TTR deposits (e.g., TTR amyloidosis) and for monitoring the efficacy of TTR therapies, among other applications.