The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 25, 2025
Filed:
Oct. 06, 2022
Janssen Pharmaceuticals, Inc., Titusville, NJ (US);
Glaxosmithkline Biologicals S.a., Rixensart, BE;
Jeroen Geurtsen, Vleuten, NL;
Pieter Jan Burghout, Pijnacker, NL;
Eveline Marleen Weerdenburg, Uithoorn, NL;
Jan Theunis Poolman, Vogelenzang, NL;
Kellen Cristhina Fae, Mainz, DE;
Patricia Ibarra Yon, Solothum, CH;
Darren Robert Abbanat, Cornwall, NY (US);
Stefan Jochen Kemmler, Zurich, CH;
Michael Thomas Kowarik, Zurich, CH;
Manuela Mally, Watt, CH;
Veronica Gambillara Fonck, Meilen, CH;
Martin Edward Braun, Cham, CH;
Maria Paula Carranza Sandmeier, Rudolfstetten, CH;
Janssen Pharmaceuticals, Inc., Titusville, NJ (US);
GlaxoSmith Kline Biologicals S.A., Rixensart, BE;
Abstract
Methods of producing bioconjugates of O-antigen polysaccharides covalently linked to a carrier protein using recombinant host cells are provided. The recombinant host cells used in the methods described herein encode a particular oligosaccharyl transferase enzyme depending on the O-antigen polysaccharide bioconjugate to be produced. The oligosaccharyl transferase enzymes can be PglB oligosaccharyl transferase or variants thereof. Also provided are compositions containing the bioconjugates, and methods of using the bioconjugates and compositions described herein to vaccinate a subject against extra-intestinal pathogenic. (ExPEC).