The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 07, 2025
Filed:
Sep. 20, 2022
Tagworks Pharmaceuticals B.v., Nijmegen, NL;
Marc Stefan Robillard, Nijmegen, NL;
Wolter Ten Hoeve, Groningen, NL;
Freek Johannes Maria Hoeben, Nijmegen, NL;
Ronny Mathieu Versteegen, Nijmegen, NL;
Henricus Marie Janssen, Nijmegen, NL;
Arthur Henry Antoon Marie Van Onzen, Nijmegen, NL;
Raffaella Rossin, Nijmegen, NL;
Tagworks Pharmaceuticals B.V., Nijmegen, NL;
Abstract
Disclosed is an advancement in provoked chemical cleavage. Thereby the invention provides the use of a diene as a chemically cleavable group attached to a Construct, and the use of a dienophile to provoke the release of the Construct by allowing the diene to react with a dienophile capable of undergoing an inverse electron demand Diels Alder reaction with the diene. The invention includes a kit for releasing a Construct Cbound to a Trigger T, the kit having a tetrazine and a dienophile, wherein the Trigger is the tetrazine. The invention also includes the use of the formation of a pyridazine by reacting a tetrazine having a Construct Cbound thereto and a dienophile, as a chemical tool for the release, in a chemical, biological or physiological environment, of the Construct.