Freek Johannes Maria Hoeben

Title: Innovations of Freek Johannes Maria Hoeben

Introduction

Freek Johannes Maria Hoeben is a notable inventor based in Nijmegen, Netherlands. He has made significant contributions to the field of bio-orthogonal drug activation. His innovative work has led to the development of a unique patent that enhances chemical cleavage processes.

Latest Patents

Hoeben holds a patent for "Cleavable tetrazine used in bio-orthogonal drug activation." This invention discloses an advancement in provoked chemical cleavage. It provides the use of a diene as a chemically cleavable group attached to a Construct. The invention also describes the use of a dienophile to provoke the release of the Construct by allowing the diene to react with a dienophile capable of undergoing an inverse electron demand Diels Alder reaction with the diene. Additionally, the invention includes a kit for releasing a Construct Cbound to a Trigger T, which contains a tetrazine and a dienophile, wherein the Trigger is the tetrazine. Furthermore, it includes the formation of a pyridazine by reacting a tetrazine having a Construct Cbound thereto and a dienophile, serving as a chemical tool for the release of the Construct in various environments.

Career Highlights

Freek Johannes Maria Hoeben is associated with Tagworks Pharmaceuticals B.V., where he continues to advance his research and development efforts. His work is pivotal in the pharmaceutical industry, particularly in drug activation technologies.

Collaborations

Some of his notable coworkers include Marc Stefan Robillard and Wolter Ten Hoeve. Their collaborative efforts contribute to the innovative environment at Tagworks Pharmaceuticals B.V.

Conclusion

Freek Johannes Maria Hoeben's contributions to the field of bio-orthogonal drug activation exemplify the impact of innovative thinking in pharmaceuticals. His patent and ongoing work continue to influence advancements in drug delivery systems.