The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 31, 2024
Filed:
Jul. 22, 2021
Beihao Stem Cell and Regenerative Medicine Research Institute Co., Ltd., Guangdong, CN;
Hong Guan Ltd., Beijing, CN;
Hongkui Deng, Beijing, CN;
Yang Zhao, Beijing, CN;
Ting Zhao, Beijing, CN;
Jingyang Guan, Beijing, CN;
Xu Zhang, Beijing, CN;
Yao Fu, Beijing, CN;
Junqing Ye, Beijing, CN;
BeiHao Stem Cell and Regenerative Medicine Research Institute Co., Ltd., Guangdong, CN;
Hong Guan Ltd., Beijing, CN;
Abstract
Provided are chemical inducers of pluripotency (CIP) which include glycogen synthase kinase inhibitors, TGFβ receptor inhibitors, cyclic AMP agonists and S-adenosylhomocysteine hydrolase (SAH) inhibitors or histone acetylators. A method of inducing pluripotency in a partially or completely differentiated cell by using such chemical inducers of pluripotency is also provided. The method includes: (i) contacting a cell with the CIPs for a sufficient period of time to result in reprograming the cell into a pluripotent stem cell having ESC-like characteristics (CiPSC). Isolated chemically induced pluripotent stem cells (CiPSCs) and their progeny, produced by inducing differentiation of the CiPSCs, can be used in a number of applications, including but not limited to cell therapy and tissue engineering.