The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 12, 2023
Filed:
Nov. 09, 2021
Applicant:
New England Biolabs, Inc., Ipswich, MA (US);
Inventors:
Chaithanya Ponnaluri, Ipswich, MA (US);
Hang-Gyeong Chin, Ipswich, MA (US);
Pierre O. Esteve, Ipswich, MA (US);
Sriharsa Pradhan, Ipswich, MA (US);
Assignee:
New England Biolabs, Inc., Ipswich, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2018.01); C12Q 1/6886 (2018.01); C12Q 1/6806 (2018.01); C12Q 1/6841 (2018.01); C12Q 1/6869 (2018.01); C12Q 1/6827 (2018.01);
U.S. Cl.
CPC ...
C12Q 1/6886 (2013.01); C12Q 1/6806 (2013.01); C12Q 1/6827 (2013.01); C12Q 1/6841 (2013.01); C12Q 1/6869 (2013.01); C12Q 2521/301 (2013.01); C12Q 2521/331 (2013.01); C12Q 2525/117 (2013.01); C12Q 2527/156 (2013.01); C12Q 2531/119 (2013.01); C12Q 2535/122 (2013.01); C12Q 2543/10 (2013.01); C12Q 2563/131 (2013.01); C12Q 2565/133 (2013.01); C12Q 2600/154 (2013.01);
Abstract
Provided herein, among other things, are various compositions and methods for analyzing chromatin. In some embodiments, the composition may comprise a mixture of a nicking enzyme, four dNTPs, at least one labeled dNTP and, optionally, a polymerase. In some embodiments, this method may comprise: obtaining a sample comprising chromatin, reacting the sample with the composition to selectively label the open chromatin in the sample, and analyzing the labeled sample.