The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 12, 2023
Filed:
Feb. 06, 2017
President and Fellows of Harvard College, Cambridge, MA (US);
The General Hospital Corporation, Boston, MA (US);
Nisarg J. Shah, Somerville, MA (US);
Ting-Yu Shih, Brookline, MA (US);
Angelo Mao, Somerville, MA (US);
David J. Mooney, Sudbury, MA (US);
David T. Scadden, Weston, MA (US);
President and Fellows of Harvard College, Cambridge, MA (US);
The General Hospital Corporation, Boston, MA (US);
Abstract
Disclosed are compositions and related methods of recapitulating bone marrow stroma using scaffold materials (e.g., a porous alginate hydrogel scaffold) containing one or more cellular differentiation factors, and one or more growth factors. Such methods and compositions promote the formation of an ectopic nodule or site that can improve transplanted cell engraftment and selectively drive the development of lymphocytes and the reconstitution of the adaptive immunity after hematopoietic stem cell transplant.