The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 05, 2023
Filed:
Oct. 03, 2016
Masarykova Univerzita, Brno, CZ;
Enantis S.r.o., Brno, CZ;
Petr Dvorak, Ricmanice, CZ;
Pavel Krejci, Brno-Venkov, CZ;
Lukas Balek, Klimkovice, CZ;
Livia Eiselleova, Mocenok, SK;
Zaneta Konecna, Pardubice, CZ;
Pavel Dvorak, Brno, CZ;
David Bednar, Brno, CZ;
Jan Brezovsky, Brno, CZ;
Eva Sebestova, Tisnov, CZ;
Radka Chaloupkova, Zamberk, CZ;
Veronika Stepankova, Slavkov u Brna, CZ;
Pavel Vanacek, Slavkov u Brna, CZ;
Zbynek Prokop, Brno, CZ;
Jiri Damborsky, Brno, CZ;
Michaela Bosakova, Brno, CZ;
Masarykova Univerzita, Brno, CZ;
Enantis s.r.o., Brno, CZ;
Abstract
The invention provides an isolated thermostable polypeptide possessing FGF2 activity and having at least 85% sequence identity to SEQ ID NO: 2 (FGF2 wt) or a functional fragment thereof, and comprising at least one amino acid substitution R31L and the use thereof in the cell biology research, regenerative medicine and related medical applications or cosmetics. Further it discloses a culture medium comprising subjected FGF2 suitable for culturing a human pluripotent stem cells involving both human embryonic stem cells and induced pluripotent stem cells.