The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 08, 2023
Filed:
Jun. 21, 2018
Wave Life Sciences Ltd., Singapore, SG;
David Charles Donnell Butler, Medford, MA (US);
Christopher P. Hencken, Boston, MA (US);
Naoki Iwamoto, Brighton, MA (US);
Pachamuthu Kandasamy, Belmont, MA (US);
Alvaro Andres Lanao, Boston, MA (US);
Genliang Lu, Winchester, MA (US);
Mamoru Shimizu, Arlington, MA (US);
Sethumadhavan Divakaramenon, Lexington, MA (US);
Chandra Vargeese, Schwenksville, PA (US);
Gopal Reddy Bommineni, Belmont, MA (US);
Subramanian Marappan, Acton, MA (US);
WAVE LIFE SCIENCES LTD., Singapore, SG;
Abstract
The present disclosure, among other things, provides technologies for synthesis, including reagents and methods for stereoselective synthesis. In some embodiments, the present disclosure provides compounds useful as chiral auxiliaries. In some embodiments, the present disclosure provides reagents and methods for oligonucleotide synthesis. In some embodiments, the present disclosure provides reagents and methods for chirally controlled preparation of oligonucleotides. In some embodiments, technologies of the present disclosure are particularly useful for constructing challenging internucleotidic linkages, providing high yields and stereoselectivity.