The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 11, 2023
Filed:
Jul. 23, 2021
Beijing Jincheng Taier Pharmaceutical Co., Ltd., Beijing, CN;
Zhen Liu, Beijing, CN;
Dongye Xing, Beijing, CN;
Zhongzheng Zhang, Beijing, CN;
Jie Li, Beijing, CN;
Yangong Han, Beijing, CN;
Yali Cui, Beijing, CN;
Liru Wang, Beijing, CN;
Hongliang Liu, Beijing, CN;
Yan Mi, Beijing, CN;
Li Li, Beijing, CN;
Jingang Tang, Beijing, CN;
Yi Kang, Beijing, CN;
Beijing Jincheng Taier Pharmaceutical Co., Ltd., Beijing, CN;
Abstract
The present disclosure relates to the technical field of drug synthesis, in particular to a method for preparing lornoxicam. The method includes the following steps: using 6-chloro-4-hydroxy-2-methyl-2-H-thieno[2,3-e]-1,2-thiazine methyl carboxylate-1,1-dioxide and 2-aminopyridine as raw materials, and xylene as a solvent; mixing the raw material and solvent, and adding a stabilizer, to obtain a mixture; subjecting the mixture to an ammonolysis; cooling the resulting reactant; conducting a vacuum concentration to remove the solvent; adding an organic solvent and slurrying, and filtering, to obtain a crude lornoxicam; and refining the crude lornoxicam to obtain the lornoxicam. In the present disclosure, p-toluenesulfonic acid is used as a stabilizer to reduce the reaction temperature and promote the reaction to proceed forward, thereby improving the quality and yield of the product.