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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11697635 B1

PDFFull Text
Date of Patent:
Jul. 11, 2023

Filed:

Oct. 16, 2018

Procedure for crystallization of (22e)-(24r)-2-methylene-22-dehydro-1α,24-25-trihydroxy-19-nor-vitamin d

Applicant:

Wisconsin Alumni Research Foundation, Madison, WI (US);

Inventors:

Hector F. Deluca, Deerfield, WI (US);

Margaret Clagett-Dame, Deerfield, WI (US);

Lori Plum, Arena, WI (US);

Agnieszka Flores, Sun Prairie, WI (US);

James Thoden, Madison, WI (US);

Hazel Holden, Fitchburg, WI (US);

Assignee:

WISCONSIN ALUMNI RESEARCH FOUNDATION, Madison, WI (US);

Attorney:

Quarles & Brady LLP

Primary Examiner:

Rosalynd A Keys

Int. Cl.
CPC ...
C07C 401/00 (2006.01); A61P 3/02 (2006.01); A61P 3/04 (2006.01); A61K 31/593 (2006.01); A61P 35/00 (2006.01); C07C 35/21 (2006.01); C07C 29/78 (2006.01);
U.S. Cl.
CPC ...
C07C 401/00 (2013.01); A61K 31/593 (2013.01); A61P 3/02 (2018.01); A61P 3/04 (2018.01); A61P 35/00 (2018.01); C07C 29/78 (2013.01); C07C 35/21 (2013.01); C07B 2200/13 (2013.01); C07C 2601/14 (2017.05); C07C 2602/24 (2017.05);
Abstract

Disclosed are methods of purifying the compound (22E)-(24R)-2-methylene-22-dehydro-1α,24,25-trihydroxy-19-nor-vitamin Dto obtain the compound in crystalline form. The methods typically include the steps of dissolving (22E)-(24R)-2-methylene-22-dehydro-1α,24,25-trihydroxy-19-nor-vitamin Din a solvent comprising ethyl acetate and hexane to form a solution, allowing crystals of (22E)-(24R)-2-methylene-22-dehydro-1α,24,25-trihydroxy-19-nor-vitamin Dto form and precipitate from the solution, and recovering the crystals of (22E)-(24R)-2-methylene-22-dehydro-1α,24,25-trihydroxy-19-nor-vitamin Dfrom the solution.

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