The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 20, 2023
Filed:
Jul. 27, 2020
Institut Pasteur, Paris, FR;
Centre National DE LA Recherche Scientifique (Cnrs), Paris, FR;
Sorbonne Université, Paris, FR;
Université Clermont Auvergne, Clermont-Ferrand, FR;
Christine Petit, Paris, FR;
Paul Avan, Clermont-Ferrand, FR;
Sedigheh Delmaghani, Paris, FR;
Jean Defourny, Paris, FR;
Asadollah Aghaie, Paris, FR;
Saaid Safieddine, Paris, FR;
Alice Emptoz, Paris, FR;
INSTITUT PASTEUR, Paris, FR;
Centre National de la Recherche Scientifique (CNRS), Paris, FR;
Universite Clermont Auvergne, Clermont-Ferrand, FR;
Sorbonne Universite, Paris, FR;
Abstract
The present invention relates to the use of gasdermin, in particular of gasdermin A, gasdermin B, gasdermin C, gasdermin D, DFNA5 or DFNB59 (or pejvakin), and more particularly pejvakin for modulating cellular redox homeostasis. A particularly preferred use of gasdermin, in particular of gasdermin A, gasdermin B, gasdermin C, gasdermin D, DFNA5 or DFNB59 (or pejvakin), and more particularly pejvakin in the context of the present invention is as an antioxidant. The present invention also concerns a virally-mediated gene therapy for restoring genetically-impaired auditory and vestibular functions in subjects suffering from an Usher syndrome. More precisely, this gene therapy takes advantage of an AAV2/8 vector expressing at least one USH1 gene product, preferably SANS.