The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 21, 2023
Filed:
Apr. 27, 2018
The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD (US);
The Government of the United States, As Represented BY the Secretary of the Army, Fort Detrick, MD (US);
Sheetij Dutta, Silver Spring, MD (US);
Zoltan Beck, Rockville, MD (US);
Carl Alving, Bethesda, MD (US);
Gary Matyas, Olney, MD (US);
The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD (US);
The Government Of The United States, As Represented By The Secretary Of The Army, Fort Detrick, MD (US);
Abstract
The invention relates to pharmaceutical compositions comprising at least one antigen and an adjuvant composition, where the adjuvant composition comprises a saponin and a liposome. The liposome of the composition comprises monophosphoryl lipid A (MPLA), cholesterol and a phospholipid that is in a liquid crystalline state at greater than or equal to 23° C., and the concentration of cholesterol to lipid in the liposome is greater than 50% (mol/mol). The antigen in the composition is a solublerecombinant circumsporozoite protein (rCSP) comprising the amino acid sequence of SEQ ID NO:1, or arCSP peptide that is at least 95% identical to the amino acid sequence of SEQ ID NO:1.