The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 29, 2022
Filed:
Feb. 12, 2020
Pact Pharma, Inc., South San Francisco, CA (US);
Songming Peng, San Mateo, CA (US);
Boi Bryant Quach, San Mateo, CA (US);
Duo An, San Mateo, CA (US);
Xiaoyan Robert Bao, Foster City, CA (US);
Alex Franzusoff, El Granada, CA (US);
Barbara Sennino, San Francisco, CA (US);
Olivier Dalmas, San Carlos, CA (US);
Stefanie Mandl-Cashman, San Francisco, CA (US);
PACT PHARMA, INC., South San Francisco, CA (US);
Abstract
Disclosed herein are antigenic peptide-MHC complexes, termed comPACT polypeptides and comPACT polynucleotides, and methods of producing such complexes. Also discloses herein are methods of producing libraries of comPACT polynucleotides and polypeptides, and their exemplary use in capturing cancer neoepitope-reactive T cells with high accuracy. Dual particle detection approaches for detection of neoantigen specific T cells with improved sensitivity and specificity are provided. Signal to noise ratio analysis of isolated T cells for detection of neoantigen-specific T cells with improved T cells is also provided.