The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 15, 2022
Filed:
Jul. 20, 2018
Amgen Research (Munich) Gmbh, Munich, DE;
Amgen Inc., Thousand Oaks, CA (US);
Shouhua Xiao, Foster City, CA (US);
Zheng Pan, Fremont, CA (US);
Dineli Wickramasinghe, San Francisco, CA (US);
M. Shawn Jeffries, Indianapolis, IN (US);
Chadwick Terence King, North Vancouver, CA;
Brian Mingtung Chan, Port Coquitlam, CA;
Peter Kufer, Munich, DE;
Ralf Lutterbüse, Munich, DE;
Tobias Raum, Munich, DE;
Patrick Hoffmann, Munich, DE;
Doris Rau, Munich, DE;
Roman Kischel, Munich, DE;
Bryan Lemon, Mountain View, CA (US);
Holger Wesche, San Francisco, CA (US);
AMGEN RESEARCH (MUNICH) GMBH, Munich, DE;
AMGEN INC., Thousand Oaks, CA (US);
Abstract
The invention provides a bispecific antibody construct comprising a first human binding domain capable of binding to human CDH19 on the surface of a target cell and a second domain capable of binding to human CD3 on the surface of a T cell. Moreover, the invention provides a nucleic acid encoding the antibody construct, a vector comprising the nucleic acid and a host cell transformed or transfected with the vector. Furthermore, the invention provides a process for the production of the bispecific antibody construct, a medical use of the antibody construct and a kit comprising the antibody construct. The bispecific antibody construct may be useful in the treatment of melanoma.