The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 01, 2022
Filed:
May. 01, 2018
Wayne State University, Detroit, MI (US);
Universitat Zurich, Zurich, CH;
Erik C. Bottger, Zurich, CH;
Sven N. Hobbie, Zurich, CH;
Andrea Vasella, Zurich, CH;
David Crich, Detroit, MI (US);
Amr Sonousi, Detroit, MI (US);
Takayuki Kato, Detroit, MI (US);
Jonathan Quirke, Detroit, MI (US);
Parasuraman Rajasekaran, Detroit, MI (US);
Vikram Ashok Sarpe, Detroit, MI (US);
WAYNE STATE UNIVERSITY, Detroit, MI (US);
UNIVERSITAT ZURICH, Zurich, CH;
Abstract
The invention relates to derivatives of apramycin-based aminoglycoside antibacterial drugs modified in positions C5 and/or C6 and O5 and/or O6. The modifications impart favourable properties regarding increased selectivity and retention of activity in the presence of resistance determinants of the AAC(3) class. The invention further relates to said compounds for use in the therapy of bacterial infection by systemic administration, especially in instances where the infection is caused by a pathogen comprising a resistance determinant of the AAC(3) class, in particular AAC(3)-IV.