The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 05, 2022
Filed:
Mar. 02, 2017
Lonza Ltd, Visp, CH;
Wieland Reichelt, Vienna, AT;
Christoph Herwig, Vienna, AT;
Julian Kager, Vienna, AT;
Patrick Sagmeister, Vienna, AT;
Matthias Funke, Naters, CH;
LONZA LTD, Visp, CH;
Abstract
A method for producing a recombinant protein of interest (POI) is provided, comprising the steps of (a) culturing cells in a cell culture medium to express said POI by adding a feed comprising at least one substrate to said cell culture, (b) applying a feeding strategy based on calculating, setting and optionally controlling the specific substrate uptake rate qof the cells during the induction phase and/or production phase of the POI, wherein qis set to be close to the maintenance rate of the cell culture; and (c) isolating said POI from the cell culture.