The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 26, 2021
Filed:
Nov. 04, 2020
Nkarta, Inc., South San Francisco, CA (US);
James Barnaby Trager, Albany, CA (US);
Luxuan Guo Buren, San Francisco, CA (US);
Chao Guo, San Francisco, CA (US);
Mira Tohmé, San Francisco, CA (US);
Ivan Chan, Millbrae, CA (US);
Alexandra Leida Liana Lazetic, San Jose, CA (US);
Nkarta, Inc., South San Francisco, CA (US);
Abstract
Several embodiments provided for relate to methods of using of anti-CD19 CAR expressing immune cells in immunotherapy. Provided for herein in several embodiments are immune cell-based (e.g., natural killer (NK) cell) compositions comprising CD19-directed chimeric antigen receptors. In some, embodiments the anti-CD19 binder portion of the CAR is humanized. In several embodiments, the humanized anti-CD19 CAR expressing cells exhibit enhanced expression of the CAR as well as enhanced cytotoxicity and/or persistence.