The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 14, 2021

Filed:

Dec. 18, 2018
Applicant:

The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Silver Spring, MD (US);

Inventors:

Gregory A. Price, Silver Spring, MD (US);

Che-Hung Robert Lee, Silver Spring, MD (US);

Margaret C. Bash, Silver Spring, MD (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/095 (2006.01); A61K 39/02 (2006.01); A61P 31/04 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/095 (2013.01); A61K 39/107 (2013.01); A61P 31/04 (2018.01); A61K 2039/6037 (2013.01); A61K 2039/6068 (2013.01); A61K 2039/70 (2013.01);
Abstract

Immunogenic compositions that include a bacterial capsular polysaccharide conjugated to a carrier protein are described. In some embodiments, the bacterial capsular polysaccharide is acapsular polysaccharide. The carrier protein includes anfactor H binding protein (fHbp) linked to cholera toxin subunit B (CTB). Administration of the immunogenic compositions elicits an immune response that includes production of meningococcal polysaccharide-specific and fHbp-specific antibodies. Use of the immunogenic compositions as meningococcal vaccines is also described.


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