The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 24, 2021

Filed:

Nov. 10, 2020
Applicant:

Agenus Inc., Lexington, MA (US);

Inventors:

Yanping Xiao, Brookline, MA (US);

Nicholas Stuart Wilson, San Carlos, CA (US);

Benjamin Maxime Morin, Somerville, MA (US);

Mark Arthur Findeis, Belmont, MA (US);

Cornelia Anne Mundt, Lörrach, DE;

Marc van Dijk, Bosch en Duin, NL;

Dhan Sidhartha Chand, Woburn, MA (US);

David Adam Savitsky, Boxford, MA (US);

Dennis John Underwood, Jamaica Plain, MA (US);

Olga Ignatovich, Cambridge, GB;

Assignee:

Agenus Inc., Lexington, MA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); C12N 15/09 (2006.01); A61K 47/68 (2017.01); A61K 39/395 (2006.01); A61K 45/06 (2006.01); A61K 51/10 (2006.01); C07K 16/46 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/28 (2013.01); A61K 39/39558 (2013.01); A61K 45/06 (2013.01); A61K 47/6883 (2017.08); A61K 51/10 (2013.01); C07K 16/2818 (2013.01); C07K 16/2875 (2013.01); C07K 16/2878 (2013.01); C07K 16/468 (2013.01); C12N 15/09 (2013.01); A61K 2039/572 (2013.01); A61K 2039/577 (2013.01); C07K 2317/33 (2013.01); C07K 2317/34 (2013.01); C07K 2317/72 (2013.01); C07K 2317/75 (2013.01);
Abstract

The instant disclosure provides antibodies that specifically bind to CD137 (e.g., human CD137) and increases CD137 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.


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