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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11022614 B1

PDFFull Text
Date of Patent:
Jun. 01, 2021

Filed:

Oct. 22, 2015

Antibodies binding to trimeric tnf alpha epitopes

Applicants:

Ucb Biopharma Srl, Brussels, BE;

Sanofi, Paris, FR;

Inventors:

James Philip O'Connell, Slough, GB;

John Robert Porter, Slough, GB;

Alastair Lawson, Slough, GB;

Tracy Lynn Arakaki, Slough, GB;

Daniel John Lightwood, Slough, GB;

Rebecca Jayne Munro, Slough, GB;

Assignee:

UCB Biopharma SRL, Brussels, BE;

Attorney:

Medler Ferro Woodhouse & Mills PLLC

Primary Examiner:

Elly-Gerald Stoica

Int. Cl.
CPC ...
C07K 14/525 (2006.01); C07K 16/24 (2006.01); G01N 33/68 (2006.01); C07D 401/14 (2006.01); C07D 471/00 (2006.01); C07K 14/705 (2006.01); C07D 213/72 (2006.01); C07D 235/04 (2006.01); C07D 239/26 (2006.01); C07D 471/04 (2006.01); A61K 47/64 (2017.01); A61P 37/00 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
G01N 33/6845 (2013.01); A61K 47/6425 (2017.08); A61P 35/00 (2018.01); A61P 37/00 (2018.01); C07D 213/72 (2013.01); C07D 235/04 (2013.01); C07D 239/26 (2013.01); C07D 401/14 (2013.01); C07D 471/00 (2013.01); C07D 471/04 (2013.01); C07K 14/525 (2013.01); C07K 14/70575 (2013.01); C07K 16/241 (2013.01); G01N 33/6854 (2013.01); G01N 33/6863 (2013.01); C07K 2317/55 (2013.01); C07K 2317/92 (2013.01); G01N 2333/525 (2013.01); G01N 2500/02 (2013.01);
Abstract

It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Antibodies which selectively bind to complexes of such compounds with TNF superfamily members are disclosed. These antibodies may be used to detect further compounds with the same activity, and as target engagement biomarker.

Find Patent Forward Citations

O'Connell, James. (2021). Antibodies binding to trimeric tnf alpha epitopes (U.S. Patent No. 11022614). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11022614

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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