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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10870627 B1

PDFFull Text
Date of Patent:
Dec. 22, 2020

Filed:

Sep. 22, 2017

Salt of quinazoline derivative, preparation method therefor and application thereof

Applicant:

Shanghai Pharmaceuticals Holding Co., Ltd., Shanghai, CN;

Inventors:

Guangxin Xia, Shanghai, CN;

Di Li, Shanghai, CN;

Ning Zhou, Shanghai, CN;

Ao Chen, Shanghai, CN;

Liang Zhao, Shanghai, CN;

Jiansheng Han, Shanghai, CN;

Yanjun Liu, Shanghai, CN;

Assignee:

SHANGHAI PHARMACEUTICALS HOLDING CO., LTD., Shanghai, CN;

Attorneys:

Houston Beshining Law Office PLLC

Liangang Ye

Primary Examiner:

Mark L Shibuya

Assistant Examiner:

Ebenezer O Sackey

Int. Cl.
CPC ...
C07D 239/94 (2006.01); A61P 35/00 (2006.01); C07C 59/265 (2006.01); C07C 309/05 (2006.01); C07C 309/29 (2006.01); C07C 59/105 (2006.01); C07C 59/255 (2006.01); C07C 65/11 (2006.01); C07C 309/35 (2006.01); C07C 59/305 (2006.01); C07C 69/38 (2006.01); C07C 69/40 (2006.01); C07C 59/347 (2006.01); C07C 57/145 (2006.01); C07C 55/08 (2006.01); C07C 55/10 (2006.01); C07C 309/39 (2006.01); C07D 401/12 (2006.01); C07D 405/12 (2006.01); C07D 413/12 (2006.01); C07D 319/12 (2006.01); C07D 307/06 (2006.01); C07D 403/12 (2006.01); C07F 9/6512 (2006.01); C07D 307/08 (2006.01); C07F 9/6558 (2006.01); A61K 31/5377 (2006.01); A61K 31/517 (2006.01);
U.S. Cl.
CPC ...
C07D 239/94 (2013.01); A61K 31/517 (2013.01); A61K 31/5377 (2013.01); A61P 35/00 (2018.01); C07C 55/08 (2013.01); C07C 55/10 (2013.01); C07C 57/145 (2013.01); C07C 59/105 (2013.01); C07C 59/255 (2013.01); C07C 59/265 (2013.01); C07C 59/305 (2013.01); C07C 59/347 (2013.01); C07C 65/11 (2013.01); C07C 69/38 (2013.01); C07C 69/40 (2013.01); C07C 309/05 (2013.01); C07C 309/29 (2013.01); C07C 309/35 (2013.01); C07C 309/39 (2013.01); C07D 307/06 (2013.01); C07D 307/08 (2013.01); C07D 319/12 (2013.01); C07D 401/12 (2013.01); C07D 403/12 (2013.01); C07D 405/12 (2013.01); C07D 413/12 (2013.01); C07F 9/6512 (2013.01); C07F 9/6558 (2013.01); C07B 2200/13 (2013.01);
Abstract

A salt of a quinazoline derivative (N-[4-(3-chlorine-4-fluoroanilino)]-7-(3-morpholinepropanol)-6-(2-fluoroacrylamide)-quinazoline, the structure thereof is as represented by formula I). Compared with a known quinazoline derivative, the salt of the quinazoline derivative has one or more improved properties and at least has better water solubility, wherein a citrate, a benzene sulfonate, and an ethanedisulphonate thereof further have better crystallinity and are not easy to absorb moisture.

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