The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 15, 2020
Filed:
Sep. 18, 2017
Lipoxen Technologies Limited, London, GB;
Baxalta Incorporated, Bannockburn, IL (US);
Baxalta Gmbh, Zug, CH;
Sanjay Jain, London, GB;
Gregory Gregoriadis, London, GB;
Archana Dwivedi, London, GB;
Srijit Nath, London, GB;
Juergen Siekmann, Vienna, AT;
Stefan Haider, Prinzersdorf, AT;
Hanspeter Rottensteiner, Vienna, AT;
Peter Turecek, Klosterneuburg, AT;
Lipoxen Technologies Limited, London, GB;
Baxalta Incorporated, Bannockburn, IL (US);
Baxalta GmbH, Glattpark (Opfikon), CH;
Abstract
A water soluble polymer, in particular polysialic acid (PSA) or a modified PSA (mPSA), is conjugated to an oxidized carbohydrate moiety of a glycoprotein other than a blood coagulation protein or to a ganglioside or drug delivery system by contacting the oxidized carbohydrate moiety with the water soluble polymer, wherein said water soluble polymer contains an aminooxy group and an oxime linkage is formed between the oxidized carbohydrate moiety and the aminooxy group on the water soluble polymer or wherein said water soluble polymer contains a hydrazide group and a hydrazone linkage is formed between the oxidized carbohydrate moiety and the hydrazide group on the water soluble polymer. Conjugates of aminooxy- or hydrazide-water soluble polymer, such as PSA and mPSA, are thus obtained in which the PSA or mPSA is attached via a carbohydrate moiety.