The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 25, 2020
Filed:
Dec. 05, 2018
Baylor Research Institute, Dallas, TX (US);
Yong-Jun Liu, Gaithersburg, MD (US);
Sandra Zurawski, Midlothian, TX (US);
SangKon Oh, Baltimore, MD (US);
Shino Hanabuchi, Gaithersburg, MD (US);
Haruyuki Fujita, Gaithersburg, MD (US);
Hideki Ueno, Plano, TX (US);
Patrick Blanco, Verdelais, FR;
Hyemee Joo, Dallas, TX (US);
Baylor Research Institute, Dallas, TX (US);
Abstract
Described herein are methods and compositions for treating autoimmunity and inflammatory conditions without non-specific suppression of the host immune system. In particular, the anti-OX40L antibodies described herein are unique in that they not only inhibit the differentiation of inflammatory T cells but also promote the generation and function of regulatory T cells by inducing IL-10 and inhibiting TNF-α and by reducing aberrant Th2 cell responses. Furthermore, the methods and compositions described herein eliminate or reduce aberrant T follicular helper cell—(Tfh) responses that may contribute to the pathogenicity of autoimmune disease.