The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 25, 2020

Filed:

Oct. 12, 2015
Applicant:

Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory, Xinchang County, CN;

Inventors:

Xinde Xu, Xinchang County, CN;

Di Zhou, Xinchang County, CN;

Lihua Zhang, Xinchang County, CN;

Bin Shao, Xinchang County, CN;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/50 (2006.01); A61K 47/36 (2006.01); A61K 47/42 (2017.01); A61K 47/22 (2006.01);
U.S. Cl.
CPC ...
A61K 9/5089 (2013.01); A61K 9/5036 (2013.01); A61K 9/5057 (2013.01); A61K 47/36 (2013.01); A61K 47/42 (2013.01); A61K 47/22 (2013.01);
Abstract

The present invention provides a method of preparing highly stable microcapsule powders or microparticles containing a fat-soluble nutrient having multiple double bonds. The method includes a) dissolving the fat-soluble nutrient having multiple unsaturated double bonds to prepare an oil phase; b) dissolving a part of a capsule shell material into water to prepare an aqueous phase; c) shearing the aqueous phase and the oil phase, and mixing and emulsifying the same to obtain an emulsion; d) homogenizing the emulsion by a standard high-pressure homogenizer, to make the emulsion obtain droplets in the emulsion with an average particle diameter at a nanometer level, thereby producing a nanometer scale emulsion; e) directly adding a remaining part of the capsule shell material into the homogenized nanometer scale emulsion, and shearing, mixing, and dissolving the same to obtain a twice-embedded emulsion; and f) performing spray granulation on the twice-embedded emulsion, and drying resultant granules to obtain the highly stable microcapsule powder or microparticles.


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