The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 10, 2019
Filed:
Feb. 29, 2016
University of Washington, Seattle, WA (US);
University of Utah, Salt Lake City, UT (US);
Neil King, Seattle, WA (US);
Wesley Sundquist, Salt Lake City, UT (US);
Joerg Votteler, Salt Lake City, UT (US);
Yang Hsia, Seattle, WA (US);
David Baker, Seattle, WA (US);
Jacob Bale, Seattle, WA (US);
Marc Lajoie, Seattle, WA (US);
Gabriel Butterfield, Seattle, WA (US);
Elizabeth Gray, Seattle, WA (US);
Daniel Stetson, Seattle, WA (US);
University of Washington, Seattle, WA (US);
University of Utah Research Foundation, Salt Lake City, UT (US);
Abstract
The application discloses multimeric assemblies including multiple oligomeric substructures, where each oligomeric substructure includes multiple proteins that self-interact around at least one axis of rotational symmetry, where each protein includes one or more polypeptide-polypeptide interface ('O interface'); and one or more polypeptide domain that is capable of effecting membrane scission and release of an enveloped multimeric assembly from a cell by recruiting the ESCRT machinery to the site of budding by binding to one or more proteins in the eukaryotic ESCRT complex ('L domain'); and where the multimeric assembly includes one or more subunits comprising one or more polypeptide domain that is capable of interacting with a lipid bilayer (“M domain”), as well as membrane-enveloped versions of the multimeric assemblies.