The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 03, 2019
Filed:
Aug. 27, 2018
Codexis, Inc., Redwood City, CA (US);
Ee Lui Ang, Singapore, SG;
Oscar Alvizo, Fremont, CA (US);
Behnaz Behrouzian, Sunnyvale, CA (US);
Michael D. Clay, Menlo Park, CA (US);
Steven J. Collier, Concord, MA (US);
Ellen D. Eberhard, Fallbrook, CA (US);
Fu Fan, Singapore, SG;
Shiwei Song, Singapore, SG;
Derek J. Smith, Singapore, SG;
Magnus Widegren, Craigavon, GB;
Robert Wilson, San Francisco, CA (US);
Junye Xu, Singapore, SG;
Jun Zhu, Chandler, AZ (US);
Codexis, Inc., Redwood City, CA (US);
Abstract
The present invention relates to non-naturally occurring polypeptides useful for preparing armodafinil, polynucleotides encoding the polypeptides, and methods of using the polypeptides. The non-naturally occurring polypeptides of the present invention are effective in carrying out biocatalytic conversion of the (i) 2-(benzhydrylsulfinyl)acetamide to (−)-2-[(R)-(diphenylmethyl)sulfinyl]acetamide (armodafinil), or (ii) benzhydryl-thioacetic acid to (R)-2-(benzhydrylsulfinyl)acetic acid, which is a pivotal intermediate in the synthesis of armodafinil, in enantiomeric excess.