The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 12, 2019
Filed:
Nov. 23, 2015
Fondazione Istituto Insubrico Di Ricerca Per LA Vita, Gerenzano, IT;
Linda Cavaletti, Rovellasca, IT;
Lucia Carrano, Legnano, IT;
Monica Abbondi, Cabiate, IT;
Mara Brunati, Olgiate Comasco, IT;
Anna Taravella, Saronno, IT;
Fondazione Is. Insubrico di Ricerca per la Vita, Gerenzano, IT;
Abstract
The invention relates to a new family of proteolytic enxymes having the ability to hydrolize at a pH between 3 and 8 gluten olygopeptides which are resistant to cleavage by gastric and pancreatic enzymes and whose presence in the intestinal lumen results in toxic effects. The enzymes have been identified as endopeptidases of the S8/S53 family and are produced by anstrain. The object of the invention includes also methods for producing enzymes composition comprising the endopeptidases by cultivation of nativestrains, mutants thereof, or recombinant host cells comprising nucleic acids codifying for the endopeptidases. Said nucleic acids constitute a further object of the invention. The enzyme compositions comprising at least one endopeptidase of the invention are useful for the treatment and/or prevention of celiac sprue, dermatitis herpetiformis and any other disorder associated with gluten intolerance as ingredients of pharmaceutical formulations or as additives of foods and drinks.