The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 13, 2018
Filed:
Jan. 06, 2016
Heptares Therapeutics Limited, Welwyn Garden City, GB;
Malcolm Peter Weir, Welwyn Garden City, GB;
Richard Henderson, Cambridge, GB;
Christopher Gordon Tate, Cambridge, GB;
Francesca Magnani, Cambridge, GB;
Maria Josefa Serrano-Vega, Cambridge, GB;
Yoko Shibata, Cambridge, GB;
Antony Johannes Warne, Cambridge, GB;
Heptares Therapeutics Limited, Hertfordshire, GB;
Abstract
A method of producing a conformational specific binding partner of a GPCR, the method comprising: a) providing a mutant GPCR of a parent GPCR, wherein the mutant GPCR has increased stability in a particular conformation relative to the parent GPCR; b) providing a test compound; c) determining whether the test compound binds to the mutant GPCR when residing in a particular conformation; and d) isolating a test compound that binds to the mutant GPCR when residing in the particular formation. Methods of producing GPCRs with increased stability relative to a parent GPCR are also disclosed.