The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 23, 2018
Filed:
Oct. 08, 2015
Msd Wellcome Trust Hilleman Laboratories Pvt. Ltd., New Delhi, IN;
Davinder Gill, New Delhi, IN;
Manoj Kumar Chhikara, Delhi, IN;
Rakesh Rana, New Delhi, IN;
Juned Dalal, New Delhi, IN;
Deepti Singh, New Delhi, IN;
MSD WELLCOME TRUST HILLEMAN LABORATORIES PVT. LTD., New Delhi, IN;
Abstract
The present invention relates to an improved process of conjugation to obtain synthetic oligosaccharide-protein (OS-PR) conjugates. The process of synthetic OS-PR conjugation is a rapid process providing oligosaccharide-protein conjugates which are highly immunogenic and elicit specific and homogenous immune responses. The synthetic oligosaccharide comprising of four to eight repeating units of respective monomers and at least one in-built terminal amino linker, said synthetic polysaccharide mimics natural polysaccharide obtained from gram negative bacteria such asserogroups A, C, Y, W, X andand carrier protein is obtained from gram positive bacteria such as(tetanus toxoid) or(CRM197) or their recombinant versions. The conjugation chemistry of the said oligosaccharide-protein conjugate of the present invention is thio-ether linkage. The present invention takes complete process time in the range of 14-22 hours. The said oligosaccharide-protein conjugates are useful in production of monovalent vaccine or multivalent combination vaccines and as diagnostic tool.