The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 14, 2018
Filed:
Aug. 10, 2011
Guy Servant, San Diego, CA (US);
Hong Chang, San Diego, CA (US);
Cyril Redcrow, San Diego, CA (US);
Sumita Ray, San Diego, CA (US);
Imran Clark, Carlsbad, CA (US);
Bryan Moyer, Thousand Oaks, CA (US);
Guy Servant, San Diego, CA (US);
Hong Chang, San Diego, CA (US);
Cyril Redcrow, San Diego, CA (US);
Sumita Ray, San Diego, CA (US);
Imran Clark, Carlsbad, CA (US);
Bryan Moyer, Thousand Oaks, CA (US);
SENOMYX INC., San Diego, CA (US);
Abstract
In one aspect, the present invention relates to a mammalian cell-based high-throughput assay for the profiling and screening of human epithelial sodium channel (hENaC) cloned from a human kidney c-DNA library and is also expressed in other tissues including human taste tissue. The present invention further relates to amphibian oocyte-based medium-throughput electrophysiological assays for identifying human ENaC modulators, preferably ENaC enhancers. Compounds that modulate ENaC function in a cell-based ENaC assay are expected to affect salty taste in humans.