Location History:
- Pasadena, CA (US) (2003 - 2005)
- St. Louis, MO (US) (2005 - 2011)
Company Filing History:
Years Active: 2003-2011
Title: Innovations of Zhoufeng Chen in Angiogenesis Research
Introduction
Zhoufeng Chen is a prominent inventor based in St. Louis, MO (US). He has made significant contributions to the field of angiogenesis, particularly in understanding the molecular distinctions between arterial and venous endothelial cells. With a total of 8 patents, his work has implications for both medical research and therapeutic applications.
Latest Patents
One of Zhoufeng Chen's latest patents focuses on artery- and vein-specific proteins and their uses. His research reveals that arterial and venous endothelial cells are molecularly distinct from the earliest stages of angiogenesis. This distinction is highlighted by the expression of a transmembrane ligand called EphrinB2 on arterial cells, while its receptor, EphB4, is expressed on venous cells. Targeted disruption of the EphrinB2 gene prevents the remodeling of veins from a capillary plexus into properly branched structures. Furthermore, it also disrupts the remodeling of arteries, indicating that reciprocal interactions between pre-specified arterial and venous endothelial cells are essential for angiogenesis. This understanding can be leveraged in methods to alter angiogenesis, assess the effects of drugs on artery and vein cells, and identify and isolate these specific cell types.
Career Highlights
Zhoufeng Chen is affiliated with the California Institute of Technology, where he continues to advance research in his field. His innovative work has garnered attention and respect within the scientific community, contributing to a deeper understanding of vascular biology.
Collaborations
Zhoufeng Chen has collaborated with notable colleagues, including Hai U Wang and David J Anderson. These partnerships have further enriched his research and expanded the impact of his findings.
Conclusion
Zhoufeng Chen's contributions to the understanding of angiogenesis and the molecular distinctions between arterial and venous cells are invaluable. His innovative patents and ongoing research continue to pave the way for advancements in medical science and therapeutic strategies.