Company Filing History:
Years Active: 2008
Title: Zhiyi Xie: Innovator in Chromosomal Disorder Detection
Introduction
Zhiyi Xie is a notable inventor based in Carlsbad, CA (US). He has made significant contributions to the field of genetic diagnostics, particularly in the detection of chromosomal disorders. His innovative approach combines advanced techniques in molecular biology to enhance the accuracy of genetic testing.
Latest Patents
Zhiyi Xie holds a patent for a method titled "Detection of chromosomal disorders." This invention focuses on detecting multiple chromosomal disorders resulting from aneuploidy or specific mutations, including microdeletions. The method utilizes polymerase chain reaction (PCR) to amplify eukaryotic genomic DNA with a variety of primer oligonucleotide pairs. One primer from each pair is labeled for detection. The targeted primer pairs correspond to DNA segments from different chromosomes that indicate potential chromosomal disorders, along with a control gene. The resulting PCR products are purified, and the labeled single-stranded DNA is hybridized with a microarray containing complementary DNA oligonucleotide probes. The microarray is then imaged to diagnose the presence or absence of chromosomal disorders by comparing the results to those of the control gene and normal DNA.
Career Highlights
Throughout his career, Zhiyi Xie has worked with prominent companies in the biotechnology sector. He has been associated with Biocept, Inc. and Novartis AG, where he has contributed to advancements in genetic testing and diagnostics. His work has had a significant impact on the development of methods for identifying chromosomal abnormalities.
Collaborations
Zhiyi Xie has collaborated with esteemed colleagues, including Soonkap Hahn and Tim Watanaskul. These partnerships have fostered innovation and have been instrumental in the development of his patented technologies.
Conclusion
Zhiyi Xie's contributions to the field of genetic diagnostics, particularly through his patent for detecting chromosomal disorders, highlight his role as an innovator in biotechnology. His work continues to influence advancements in genetic testing methodologies.