Zhaozhao Li

Title: Zhaozhao Li: Innovator in Peptide Research

Introduction

Zhaozhao Li is a prominent inventor based in Alpharetta, Georgia. He has made significant contributions to the field of peptide research, particularly in the development of novel classes of peptide ketoamides. With a total of two patents to his name, his work focuses on selectively inhibiting various proteases, which are crucial in many biological processes.

Latest Patents

Zhaozhao Li's latest patents include "Heterocyclic peptide ketoamides," which represent a novel class of peptide α-ketoamides. These compounds are useful for selectively inhibiting calpains and cysteine proteases, as well as generally inhibiting all cysteine proteases. The formula for these compounds is M-AA-AA-CO—NH—(CH)—R. Additionally, he has developed processes for the synthesis of peptidyl α-ketoamide derivatives. Another significant patent is for "Peptidyl ketoamides," which are designed to selectively inhibit serine proteases and cysteine proteases, with the formula Y--CO--AA²--AA¹--CO--NH--X. These innovations provide compositions and methods for inhibiting cysteine proteases and calpains, which are essential for treating diseases caused by these proteases.

Career Highlights

Zhaozhao Li has worked with notable institutions such as Georgia Tech Research Corporation and Emory University. His research has contributed to advancements in the understanding and application of peptide-based therapies.

Collaborations

Zhaozhao has collaborated with esteemed colleagues, including James C. Powers and Girish S. Patil. Their combined expertise has furthered the impact of his research in the scientific community.

Conclusion

Zhaozhao Li's innovative work in peptide research and his contributions to the field through his patents highlight his role as a significant inventor. His advancements in selectively inhibiting proteases have the potential to lead to important therapeutic applications.