Company Filing History:
Years Active: 2001-2002
Title: Innovations in Antimicrobial and Antiviral Drug Development by Yuzhi Dong
Introduction
Yuzhi Dong is a notable inventor based in Bayside, NY (US), recognized for his contributions to the field of antimicrobial and antiviral drug development. With a total of 2 patents to his name, he has made significant strides in addressing the challenges posed by drug-resistant pathogens.
Latest Patents
Yuzhi Dong's latest patents focus on the dosing and development of antimicrobial and antiviral drugs determined by the restriction of resistant mutant selection. His invention is based on the discovery that a specific concentration of drugs can be identified at which drug-resistant mutant pathogen strains are not selected. This concentration is referred to as the "mutant prevention concentration" (MPC). Maintaining serum concentrations of the drug above the MPC throughout a treatment course is crucial for severely restricting the selection of drug-resistant mutants. Furthermore, it has been discovered that drug-resistant mutant pathogens are selected exclusively within a drug concentration window, termed the "mutant selection window" (MSW). A quantitative expression of this window, known as the "window index" (WI), is defined as the ratio of the MPC to the minimum inhibitory concentration (MIC). The window index is characteristic of a given drug and a specific pathogen.
Career Highlights
Yuzhi Dong is affiliated with the Public Health Research Institute of the City of New York, Inc., where he continues to advance research in the field of public health. His work has been instrumental in developing strategies to combat drug resistance in various pathogens.
Collaborations
Yuzhi Dong has collaborated with esteemed colleagues such as Karl A Drlica and Xilin Zhao, contributing to a collective effort in enhancing the understanding and treatment of infectious diseases.
Conclusion
Yuzhi Dong's innovative work in antimicrobial and antiviral drug development highlights the importance of addressing drug resistance in modern medicine. His discoveries pave the way for more effective treatment strategies against resistant pathogens.
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