Yokohama, Japan

Yukio Horiuchi


Average Co-Inventor Count = 5.4

ph-index = 4

Forward Citations = 40(Granted Patents)


Location History:

  • Yokohama, JA (1976 - 1978)
  • Tokyo, JP (1979)
  • Yokohama, JP (1979)

Company Filing History:


Years Active: 1976-1979

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5 patents (USPTO):Explore Patents

Title: The Innovations of Yukio Horiuchi

Introduction

Yukio Horiuchi is a notable inventor based in Yokohama, Japan. He has made significant contributions to the field of antibiotics, particularly through his innovative approaches to aminoglycosidic derivatives. With a total of five patents to his name, Horiuchi's work has had a substantial impact on the therapeutic treatment of bacterial infections.

Latest Patents

One of Horiuchi's latest patents involves a new 1-N-(.omega.-aminoalkanesulfonyl) derivative of an aminoglycosidic antibiotic. This derivative, which includes antibiotics such as ribostamycin and kanamycin, exhibits a broader antibacterial spectrum than its parent compounds. It is particularly useful in treating infections caused by both gram-positive and gram-negative bacteria, including drug-resistant strains. The process for creating this derivative involves a reaction between the parent antibiotic and an amino-protected .omega.-aminoalkanesulfonic acid halide, followed by the removal of the amino-protecting group.

Another significant patent details a process for preparing a novel antibiotic, 5'-amino-3',5'-dideoxy-ribostamycin. This process includes selective sulfonylation of a ribostamycin derivative to form a 3',5'-O-disulfonyl derivative, which is then subjected to an azide-forming reaction with sodium azide.

Career Highlights

Throughout his career, Horiuchi has worked with prominent companies in the pharmaceutical industry, including Meiji Seika Kaisha, Ltd. and the Biseibutsu Kagaku Kenkyu Kai. His work has been instrumental in advancing antibiotic research and development.

Collaborations

Horiuchi has collaborated with esteemed colleagues such as Eiichi Akita and Hamao Umezawa. These partnerships have contributed to the success of his innovative projects and the advancement of antibiotic therapies.

Conclusion

Yukio Horiuchi's contributions to antibiotic innovation highlight his role as a significant inventor in the field. His patents reflect a commitment to improving therapeutic options for bacterial infections, showcasing the importance of innovation in medicine.

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