Yuki Ohta

Title: Yuki Ohta - Innovator in Glycoprotein Analysis

Introduction

Yuki Ohta is a prominent inventor based in Yokohama, Japan. He has made significant contributions to the field of glycoprotein analysis, particularly through his innovative methods for studying N-linked sugar chains. His work has implications for various applications in biochemistry and molecular biology.

Latest Patents

Yuki Ohta holds a patent for a "Method and system for analyzing N-linked sugar chains of glycoprotein." This patent discloses a novel means for accurate qualitative and quantitative analyses for each N-glycosylation site. The method involves treating a glycopeptide-containing sample with endo-β-N-acetylglucosaminidases to cleave off sugar chains while retaining one GlcNAc of the chitobiose core on the Asn at the N-glycosylation site. The sample is then subjected to preliminary liquid chromatography/mass spectrometry, allowing for the prediction of retention time and mass-to-charge ratio of the glycopeptide of interest. This innovative approach enables the analysis of binding sites and structures of N-linked sugar chains in glycoproteins, facilitating quantitative analysis at each glycosylation site.

Career Highlights

Yuki Ohta is affiliated with the Public University Corporation Yokohama City University, where he conducts his research and development. His work has garnered attention for its potential to advance the understanding of glycoprotein structures and functions.

Collaborations

Yuki collaborates with notable colleagues, including Nana Kawasaki and Daisuke Takakura. Their combined expertise contributes to the advancement of research in glycoprotein analysis.

Conclusion

Yuki Ohta's innovative methods for analyzing N-linked sugar chains represent a significant advancement in the field of biochemistry. His contributions are poised to enhance our understanding of glycoproteins and their roles in biological processes.