Company Filing History:
Years Active: 2000
Title: Innovations in Oligonucleotide Synthesis by Yongxin Han
Introduction
Yongxin Han is a notable inventor based in Framingham, MA (US). He has made significant contributions to the field of oligonucleotide synthesis, particularly through his innovative work on sulfur transfer reagents. His research has the potential to enhance the efficiency and cost-effectiveness of oligonucleotide production.
Latest Patents
Yongxin Han holds a patent for "Sulfur transfer reagents for oligonucleotide synthesis." This patent describes the discovery of two commercially available compounds, 3-amino-1,2,4-dithiazole-5-thione and xanthane hydride, which have been identified as potential sulfur-transfer reagents. The research demonstrated that these compounds can achieve over 99% sulfur transfer efficiency during the synthesis of dinucleotide and oligonucleotide phosphorothioates. The stability of these reagents in various solvents and their availability in bulk at low cost make them promising alternatives to the Beaucage reagent.
Career Highlights
Yongxin Han's career is marked by his innovative research at Hybridon, Inc. His work has focused on optimizing sulfur-transfer reagents, which are crucial for the synthesis of oligonucleotides. The efficiency of these reagents has been a significant advancement in the field, allowing for more effective large-scale preparations.
Collaborations
Yongxin has collaborated with notable colleagues, including Jimmy X Tang and Zhoada Zhang. Their combined expertise has contributed to the successful development of new sulfur-transfer reagents.
Conclusion
Yongxin Han's contributions to the field of oligonucleotide synthesis through his innovative patent work highlight the importance of research in developing efficient and cost-effective reagents. His findings have the potential to significantly impact the production of oligonucleotides in various applications.