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Years Active: 2011-2025
Title: Yongping Yue: Innovator in Genetic Therapies
Introduction
Yongping Yue is a prominent inventor based in Columbia, MO, known for his significant contributions to the field of genetic therapies. With a total of seven patents to his name, he has made remarkable advancements in treating genetic conditions, particularly those related to muscular dystrophies and other neuromuscular disorders.
Latest Patents
Yue's latest patents include innovative approaches such as dystrophin R16/R17 syntrophin PDZ fusion proteins. These synthetic nucleic acids encode mini and microdystrophin genes that comprise membrane binding motifs or domains of the R10-R11-R12 region. His work provides vectors, host cells, and related methods aimed at treating subjects suffering from Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD), or X-linked dilated cardiomyopathy (XLDC). Additionally, he has developed a fusion protein that includes a nNOS binding domain of dystrophin R16-R17, which is operably linked to a syntrophin PDZ domain. This innovation can be utilized to treat diseases characterized by a loss of sarcolemmal neuronal nitric oxide synthase (nNOS) activity. Another significant patent involves CRISPR therapy, which outlines methods for systemically editing genes and treating genetic conditions using a dual-vector CRISPR-Cas therapy.
Career Highlights
Yongping Yue has had a distinguished career, working at esteemed institutions such as the University of Missouri and the National Institutes of Health, a component of the US Department of Health & Human Services. His research has been pivotal in advancing the understanding and treatment of genetic disorders.
Collaborations
Yue has collaborated with notable colleagues, including Dongsheng Duan and Yi Lai, contributing to the collective effort in the field of genetic research and therapy.
Conclusion
Yongping Yue's innovative work in genetic therapies has the potential to transform the treatment landscape for various genetic conditions. His patents reflect a commitment to advancing medical science and improving patient outcomes.