This inventor holds 1 USPTO granted patent and 2 published patent applications and 1 EPO patent. Top assignee: Harvard College. Active years: 2019.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile
Company Filing History:
Years Active: 2019
Title: Innovations in Kinase Activity Screening by Yonghao Yu
Introduction
Yonghao Yu is an accomplished inventor based in Roxbury, MA (US). He has made significant contributions to the field of mass spectrometry and kinase activity profiling. His innovative methods and compositions have the potential to advance research in cancer diagnostics and treatment.
Latest Patents
Yonghao Yu holds a patent titled "Methods, compositions and kits for high throughput kinase activity screening using mass spectrometry and stable isotopes." This patent describes a mass-spectrometry-based method and substrates for large-scale kinome activity profiling directly from crude lysates. The method utilizes 90 chemically synthesized peptide substrates derived from known phosphoproteins. Quantification of peptide phosphorylation rates is achieved through stable isotope labeled synthetic peptides. This innovative approach allows for 90 simultaneous activity measurements in a single-reaction format.
Career Highlights
Yonghao Yu's work has been successfully applied to various biological contexts. His method has been utilized with lysates from cells manipulated by a combination of mitogen stimulation, pharmacological perturbation, and siRNA-directed kinase knockdown. Additionally, it has been applied to seven different breast cancer cell lines treated with gefitinib, as well as normal and cancerous tissue samples from renal cell carcinoma patients. This method provides a diagnostic fingerprint pattern for activated kinases, protein phosphatases, and their pathways from minimal starting material.
Collaborations
Yonghao Yu has collaborated with notable colleagues, including Steven P. Gygi and Kazuishi Kubota. Their combined expertise has contributed to the advancement of research in kinase activity and mass spectrometry.
Conclusion
Yonghao Yu's innovative contributions to kinase activity screening represent a significant advancement in the field of mass spectrometry. His patented methods have the potential to enhance cancer diagnostics and provide valuable insights into kinase activity.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile