Xiaolu Han

Title: Innovations of Xiaolu Han in Tumor-Specific Activation

Introduction

Xiaolu Han is an accomplished inventor based in Los Angeles, CA. She has made significant contributions to the field of biomedical engineering, particularly in the development of innovative therapies for cancer treatment. Her work focuses on enhancing the effectiveness of chimeric antigen receptor (CAR) T cell therapies.

Latest Patents

Xiaolu Han holds a patent for her invention titled "Masking chimeric antigen receptor T cells for tumor-specific activation." This invention is directed to a masked chimeric antigen receptor, which comprises several key components: (a) a masking peptide, (b) one or more antigen-specific targeting domains, (c) an extracellular spacer domain, (d) a transmembrane domain, (e) at least one co-stimulatory domain, and (f) an intracellular signaling domain. The masked CARs (mCARs) are activated upon cleavage of the masking peptide, allowing for targeted activation against tumors.

Career Highlights

Xiaolu Han is affiliated with the University of Southern California, where she continues to advance her research and innovations. Her work has garnered attention for its potential to improve cancer therapies and patient outcomes.

Collaborations

Xiaolu collaborates with her coworker, Paul Bryson, to further explore the applications of her inventions in clinical settings.

Conclusion

Xiaolu Han's innovative work in the field of chimeric antigen receptor T cell therapies represents a significant advancement in cancer treatment. Her patented invention showcases her commitment to developing targeted therapies that can improve the lives of patients battling cancer.