Company Filing History:
Years Active: 2007
Title: Innovations of Wolf Scheible in Cellulose Biosynthesis
Introduction
Wolf Scheible is a notable inventor based in Golm, Germany. He has made significant contributions to the field of plant biosynthesis, particularly in the area of cellulose production. His work has implications for agriculture and herbicide resistance, showcasing the intersection of biotechnology and environmental sustainability.
Latest Patents
Wolf Scheible holds a patent related to cellulose synthase (CS), a crucial enzyme in the biosynthesis of cellulose in plants. This patent addresses the inhibition of CS by herbicides that include thiazolidinones, such as 5-tert-butyl-carbamoyloxy-3-(3-trifluromethyl)phenyl-4-thiazolidinone (TZ), isoxaben, and 2,6-dichlorobenzonitrile (DCB). His research led to the isolation of two mutant genes that encode isoxaben and TZ-resistant cellulose synthase from resistant mutants. Notably, one of the resistant CS genes features a point mutation where glycine residue 998 is replaced by aspartic acid, while the other mutation involves a threonine to isoleucine change at amino acid residue 942. This innovation allows for the development of herbicide-resistant plants, enabling the use of herbicides at concentrations that effectively eliminate weeds without harming the transgenic crop.
Career Highlights
Wolf Scheible is affiliated with the U.S. Department of Energy, where he continues to advance research in plant biotechnology. His work has garnered attention for its potential to improve agricultural practices and enhance crop resilience against herbicides.
Collaborations
Wolf Scheible has collaborated with Chris Somerville, a fellow researcher in the field. Their partnership has contributed to the advancement of knowledge in cellulose biosynthesis and herbicide resistance.
Conclusion
Wolf Scheible's innovative work in cellulose biosynthesis and herbicide resistance represents a significant advancement in agricultural biotechnology. His contributions have the potential to transform how crops are cultivated and managed in the presence of herbicides.