Company Filing History:
Years Active: 2000-2011
Title: The Innovations of William G. Dunphy
Introduction
William G. Dunphy is a prominent inventor based in Altadena, California. He has made significant contributions to the field of molecular biology, particularly in the area of DNA damage response and checkpoint regulation. With a total of 7 patents, his work has the potential to impact cancer research and therapeutic strategies.
Latest Patents
Dunphy's latest patents include groundbreaking methods for modulating checkpoint activation through TopBP1. This invention addresses the critical role of ATR kinase as a regulator of checkpoint responses to incompletely replicated and damaged DNA. By providing methods and reagents to either block or activate the ATR kinase checkpoint, his work aims to prevent premature entry into mitosis, which can lead to cell death. Additionally, he has developed screening methods to identify further TopBP1 inhibitors or activators that can modulate ATR checkpoint activity.
Another notable patent involves cloning and functional assays of Xenopus ATR. This invention provides compositions of ATR nucleic acids and proteins, along with methods for utilizing these compositions in screening assays. Furthermore, it includes antibodies and transgenic animals based on the ATR compositions, which can be valuable tools in research.
Career Highlights
Dunphy is affiliated with the California Institute of Technology, where he conducts his research and develops his inventions. His work has garnered attention in the scientific community for its innovative approach to understanding DNA damage response mechanisms.
Collaborations
Dunphy has collaborated with notable colleagues, including Akiko Kumagai and Paul R. Mueller. Their combined expertise has contributed to advancing research in the field of checkpoint regulation and DNA repair.
Conclusion
William G. Dunphy's contributions to the field of molecular biology through his patents and research are noteworthy. His innovative methods for modulating checkpoint activation and understanding ATR function hold promise for future advancements in cancer treatment and research.