Company Filing History:
Years Active: 2001
Title: The Innovations of William C. Skarnes
Introduction
William C. Skarnes is a notable inventor based in Berkeley, California. He has made significant contributions to the field of genetics, particularly in the development of gene trap vectors. His work has implications for understanding neuronal functions and gene expression in vertebrate neurons.
Latest Patents
William C. Skarnes holds a patent for his invention titled "Gene trap vectors." This invention provides methods and compositions for expressing targeted gene products in vertebrate neurons. The compositions include gene trap vectors comprising a polynucleotide that includes a promoterless selectable marker and axon reporter encoding sequences. These elements may be operatively joined to an internal ribosome-entry site and may also include a splice acceptor site located 5′ to the selectable marker and axon reporter encoding sequences. The methods involve expressing an axon reporter in a cell by transferring the subject vectors into an embryonic stem cell and incubating the cell under conditions that allow differentiation into a neuron with axons or dendrites. The neuron expresses the axon reporter under the transcriptional control of the gene, allowing for specific detection of the axon reporter in the axon or dendrites.
Career Highlights
William C. Skarnes is affiliated with the University of California, where he continues to advance research in genetics and neuroscience. His innovative approaches have garnered attention in the scientific community, contributing to the understanding of gene expression and neuronal development.
Collaborations
Throughout his career, William has collaborated with esteemed colleagues such as Marc Tessier-Lavigne and Kevin J. Mitchell. These collaborations have further enriched his research and expanded the impact of his inventions.
Conclusion
William C. Skarnes is a prominent figure in the field of genetics, with a focus on gene trap vectors that enhance our understanding of neuronal functions. His contributions continue to influence research in neuroscience and genetics.
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