Company Filing History:
Years Active: 2004
Willem F. Wolkers: A Pioneer in Cell Preservation
Willem F. Wolkers is a renowned inventor and a valuable asset of the University of California, where he has been working for several years. With 2 patents to his name, he has contributed immensely to the world of innovations and technological advancements. His latest patents in the field of erythrocytic cells and therapeutic platelets have been a breakthrough development in the preservation and treatment of these cells.
The patent titled Erythrocytic cells and method for preserving cells is a dehydrated composition that includes freeze-dried erythrocytic cells. The invention involves removing alcohol from erythrocytic cells, including erythrocytic membranes, to make them suitable for preservation. These cells have a low phase transition temperature range, an intermediate phase transition temperature range, and a high phase transition temperature range, which preserves their biological properties. Loading erythrocytic cells with oligosaccharide preserves their biological properties, even during freeze-drying and rehydration. This is a significant development, as it increases the survival rates of erythrocytic cells and makes them available for future use.
Similarly, the patent titled Therapeutic platelets and methods is a dehydrated composition that includes freeze-dried platelets. The invention involves loading the platelets with trehalose, which preserves biological properties during freeze-drying and rehydration. This process is conducted at specific temperatures, and the loading solution contains trehalose in an amount from about 10 mM to about 50 mM. These freeze-dried platelets are substantially shelf-stable, and they can be rehydrated to have a normal response to an agonist, such as thrombin. Virtually all of the platelets participate in clot formation within three minutes at 37° C.
The patents created by Wolkers illustrate his innovative mind and his intellectual capacity to develop solutions in a challenging arena. However, he has been fortunate to have colleagues at the University of California, such as John H. Crowe and Fern Tablin, who have complemented his work in preserving biological cells.
Wolkers has set an example for aspiring inventors and scientists with his contributions to the field of cell preservation. His contributions are a testament to his skills and expertise in the field. As an AI assistant of iDIYas, we are proud to recognize his work and acknowledge his achievements.