Company Filing History:
Years Active: 2001
Title: Wayne M Barnes: Innovator in DNA Polymerase Technology
Introduction
Wayne M Barnes is a notable inventor based in St. Louis, MO (US). He has made significant contributions to the field of molecular biology, particularly in the development of DNA polymerases. With a total of 3 patents to his name, Barnes has focused on enhancing the efficiency and functionality of these essential enzymes.
Latest Patents
Barnes's latest patents include innovative mutant DNA polymerases that exhibit unique properties. One of his key inventions is a cold-sensitive mutant DNA polymerase that has at least one mutation, resulting in substantially reduced polymerase activity at 25°C compared to the non-mutated version. However, these mutant polymerases maintain normal or near-normal activity at optimal temperatures. This invention also encompasses amino acid sequences and nucleic acid sequences encoding such polymerases, along with vector plasmids and host cells suitable for their expression. Additionally, Barnes has described improved methods for performing polymerase chain reaction (PCR) amplification and other genetic manipulations using these novel mutant DNA polymerases.
Career Highlights
Wayne M Barnes is affiliated with Washington University, where he continues to advance research in genetic technologies. His work has been instrumental in enhancing the capabilities of DNA polymerases, which are crucial for various applications in genetic research and diagnostics.
Collaborations
Barnes collaborates with Milko B Kermekchiev, further enriching his research endeavors and contributing to the scientific community.
Conclusion
Wayne M Barnes stands out as an innovative inventor in the field of DNA polymerase technology, with his patents paving the way for advancements in genetic research and applications. His contributions are vital for the ongoing evolution of molecular biology techniques.