Company Filing History:
Years Active: 1999-2006
Title: Innovations in Cardiac Gene Therapy by Walter J Koch
Introduction
Walter J Koch is a prominent inventor based in Durham, NC (US), known for his significant contributions to the field of cardiac gene therapy. With a total of 7 patents, Koch has focused on enhancing myocardial function through innovative gene constructs.
Latest Patents
One of his latest patents involves the use of exogenous β-adrenergic receptor and β-adrenergic receptor kinase gene constructs to enhance myocardial function. This invention addresses gene therapy for treating chronic heart failure and other cardiac diseases characterized by a reduced number or functioning of myocardial beta-adrenergic receptors (β-AR). The invention demonstrates that β-AR receptor function can be augmented in transgenic animals by delivering and expressing a beta-2-adrenergic receptor gene or a gene encoding a beta-adrenergic receptor kinase inhibitor. This results in increased in vivo left ventricular function. The patent also includes recombinant plasmid vectors, alternative beta-adrenergic receptor gene delivery strategies, and transgenic mice carrying a β-AR transgene, a β-ARK transgene, or a β-ARK inhibitor transgene. Another significant patent focuses on preventing the desensitization of receptors that control disease by inhibiting G-protein receptor kinases. This has important applications for patients with heart failure or those at high risk for cardiac events.
Career Highlights
Walter J Koch has made remarkable strides in the field of cardiac research, particularly through his work at Duke University. His innovative approaches have paved the way for new treatments and therapies that can significantly improve patient outcomes in cardiac health.
Collaborations
Koch has collaborated with notable figures in the field, including Robert J Lefkowitz and Carmelo A Milano. These partnerships have further enhanced the impact of his research and innovations.
Conclusion
Walter J Koch's contributions to cardiac gene therapy exemplify the intersection of innovation and medical science. His work continues to influence the treatment of heart diseases, showcasing the potential of gene therapy in improving myocardial function.